|
KMID : 0390119930330020209
|
|
Journal of Pusan Medical College
1993 Volume.33 No. 2 p.209 ~ p.216
|
|
|
Effects of Methylprednisolone on Lipid peroxidation and Na-K-ATPase Activity Following Experimental Spinal Cord Trauma
|
|
|
|
|
Abstract
|
|
|
The present study was undertaken to examine the ability of single large intravenous dose of methylprednisolone (30 or 60 mg/kg) to attenuate lipid peroxidation and enhance Na-K-ATPase activity during 60 minutes after 400 gm-cm injury to cat
spinal
cord.
@ES The results obtained were as follows:
@EN 1. The trauma on cat spinal cord resulted in a sudden increase of systolic and diastolic pressure. This increased pressure lasted approximately 60 minutes and then were followed by normal level. The injury induced hypertension was more
enhance
the
administration of 60 mg/kg dose of methylprednisolone.
2. The contusion injury was associated with a rise in the concentration of fluorescent lipid peroxidation produced in the injured segment at 60 minutes.
The injury induced increase in fluorescence in contused spinal segment at 60 minutes was completely prevented by the administration of 30 or 60 mg/kg dose of methylprednisolone.
3. The concomitant examination of the acute effect of methylprednisolone on Mg-ATPase activity in the injured cord revealed no striking increase of enzyme activity. This result demonstrated that a single massive dose of administration could
reduce
lipid peroxidation as well as enhance Na-K-ATPase activity.
4. In vitro, methylprednisolone was not responsible to Na-K-ATPase activity.
In summary, these results demonstrate that a massive dose of methylprednisolone can beneficially reduce lipid peroxidation as well as enhance activity of neuronal Na-K-ATPase during the early phase after spinal cord trauma.
It suggests that this enhancement of Na-K-ATPase activity is related to the reduction of lipid peroxidation and these findings impress the role for a recovery in central nervous trauma.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|